Name: Creamy Chicken Alfredo Lasagna Roll-Ups Recipe
Prep time: 15 min
Cook time: 35 min
Total time: 50 min
Cuisine: Italian
Ingredients: 12 uncooked lasagna noodles; 1 teaspoon salt (for boiling noodles); ⅓ cup butter; 3 cloves garlic, minced; 1 tablespoon all-purpose flour; 1 ½ cups milk (2% or whole); 1 cup heavy whipping cream; ¾ cup parmesan cheese, grated; ½ teaspoon salt; ¼ teaspoon ground black pepper; ⅛ teaspoon ground nutmeg (optional); 3 cups cooked shredded chicken; 2 cups shredded mozzarella cheese, divided; 2 tablespoons chopped fresh parsley

Nothing beats the cozy comfort of a creamy, cheesy dinner that just feels like a hug on a plate. That’s exactly why I adore this Creamy Chicken Alfredo Lasagna Roll-Ups Recipe—it combines rich Alfredo sauce with tender shredded chicken wrapped in delicate pasta, all baked until bubbly and golden. Trust me, it’s a showstopper!

A close-up view of a single piece of baked lasagna being lifted on a wooden spatula showing three layers of wavy pasta sheets in light yellow color. Between the pasta layers, there is creamy white cheese sauce, thick and smooth, melting slightly with a bubbly texture. The top layer is a golden brown cheese crust with small green herb bits sprinkled on it. The melted cheese stretches down in thin strings from the lasagna. The background surface is white marble with soft lighting. photo taken with an iphone --ar 2:3 --v 7

Jump to:

Why You'll Love This Recipe
Ingredients & Why They Work
Make It Your Way
Step-by-Step: How I Make Creamy Chicken Alfredo Lasagna Roll-Ups Recipe
Top Tip
How to Serve Creamy Chicken Alfredo Lasagna Roll-Ups Recipe
Make Ahead and Storage
Frequently Asked Questions:
Final Thoughts
Creamy Chicken Alfredo Lasagna Roll-Ups Recipe

Why You'll Love This Recipe

I remember making this for my family on a chilly weekend, and the whole kitchen smelled like a little Italian trattoria. Everyone loved how creamy yet light the rolls felt, and how the chicken made everything hearty without being heavy. It’s so worth the little effort!

Easy to Assemble: Rolling the noodles with the filling is simpler than it sounds—once you get the hang of it, it’s actually kind of fun.
Creamy & Comforting: The Alfredo sauce is rich but balanced, making each bite melt in your mouth perfectly.
Make-Ahead Friendly: You can prep in advance and bake when ready, which is great for busy nights.
Customizable: Whether you want to add veggies or switch up the cheese, this recipe is a great canvas for your favorites.

A white baking dish filled with six pieces of baked pasta rolls arranged in two rows of three. Each roll has a light yellow pasta layer wrapped around a creamy filling visible at the edges. The top is covered with a thick layer of melted cheese browned in spots with golden and light brown patches. Small bits of green herbs are sprinkled over the cheese. The dish sits on a white marbled surface. photo taken with an iphone --ar 2:3 --v 7

Ingredients & Why They Work

The magic here comes from simple, classic ingredients that blend into a creamy sauce enveloping tender chicken and pasta. Picking quality Parmesan and fresh mozzarella really makes the difference, and using both milk and heavy cream gives the sauce that silky texture without weighing it down.

Flat lay of uncooked lasagna noodles neatly stacked, a small white ceramic bowl of softened butter, three whole uncracked garlic cloves, a small white bowl of all-purpose flour, two small white bowls—one filled with fresh 2% milk and one with heavy whipping cream, a simple white bowl holding grated parmesan cheese, a small white bowl of shredded cooked chicken, a small white bowl of shredded mozzarella cheese, a small white bowl containing chopped fresh parsley, and small white bowls with salt, ground black pepper, and ground nutmeg placed symmetrically, all ingredients fresh and natural, arranged with perfect balance and symmetry, placed on a clean white marble surface, soft natural light, photo taken with an iPhone, professional food photography style, fresh ingredients, white ceramic bowls, no bottles, no duplicates, no utensils, no packaging --ar 2:3 --v 7 --p m7354615311229779997

Lasagna noodles: The sturdy pasta holds up when rolled and baked, and cooking them al dente ensures they don’t become mushy.
Salt: Essential both in pasta water and sauce to enhance all the flavors.
Butter: Creates the base for a smooth roux, enriching the sauce with a deep buttery flavor.
Garlic: Adds a subtle aromatic kick without overpowering the creaminess.
All-purpose flour: Thickens the sauce gently, giving it body and creaminess.
Milk (2% or whole): Keeps the sauce light and balanced with the richer heavy cream.
Heavy whipping cream: Gives that irresistible velvety texture and richness.
Parmesan cheese: Sharp, nutty, and melts beautifully, it deepens the flavor profile.
Ground black pepper: Just the right touch of heat to lift the richness.
Ground nutmeg (optional): A pinch adds warmth and complexity—you can skip it, but I love how it rounds out the sauce.
Cooked shredded chicken: Adds a hearty, protein-packed element that’s tender and flavorful.
Mozzarella cheese: Melts wonderfully for gooey, stringy goodness on top and inside.
Fresh parsley: Brightens the dish with a pop of color and freshness as a garnish.

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Note: You'll find the complete list of ingredients, along with their exact measurements, in the printable recipe card at the bottom of this post.

Make It Your Way

I love to tweak this Creamy Chicken Alfredo Lasagna Roll-Ups Recipe depending on what’s in my fridge or my mood. Sometimes I add a handful of sautéed spinach inside for an extra veggie hit, and other times I swap the chicken for some spicy Italian sausage for a punchier flavor.

Vegetarian Variation: Skip the chicken and add roasted mushrooms or zucchini ribbons for a delicious veggie-forward version I’ve made that everyone enjoyed.
Make it lighter: Using half-and-half instead of heavy cream cuts calories slightly while keeping that creamy texture, perfect if you want something a bit lighter but still indulgent.
Extra cheesy: I sometimes sprinkle extra mozzarella on top before baking to get that perfectly golden, bubbly crust everyone swoons over.

Step-by-Step: How I Make Creamy Chicken Alfredo Lasagna Roll-Ups Recipe

Step 1: Cook Pasta Perfectly

Start by boiling those lasagna noodles in salted water until they’re just al dente—not too soft because you want them pliable, but still firm enough to hold their shape when rolling. Once done, drain them and keep them submerged in cool water to stop cooking and prevent sticking. This little trick has saved me from noodle mishaps more than once!

Step 2: Whip Up the Creamy Alfredo Sauce

Over medium heat, melt the butter and sauté fresh garlic just for a minute until you can smell that garlic goodness—don’t let it brown or it’ll get bitter! Then sprinkle in the flour and stir for another minute to cook out the raw taste. Slowly whisk in milk and heavy cream, letting it gently simmer and thicken. Finally, add Parmesan cheese, salt, pepper, and the optional nutmeg. Stir until it’s luxuriously smooth—if it gets too thick, a splash of milk opens it right back up.

Step 3: Combine Chicken & Cheese

In a mixing bowl, spoon in 1 cup of the Alfredo sauce, and stir in the shredded chicken and 1 cup of mozzarella cheese. Season lightly with salt and pepper. This combo is the creamy, comforting center of your roll-ups that makes everyone sigh happily when they take the first bite.

Step 4: Roll Them Up and Bake

Spread a thin layer of Alfredo sauce on the bottom of your greased baking dish to keep those roll-ups from sticking and add extra saucy goodness. Then lay out each noodle flat, spread a layer of the chicken mixture, and roll it up gently but snugly. Place seam side down in your pan. Top everything with the remaining Alfredo sauce and sprinkle the rest of the mozzarella cheese on top. Bake at 375°F/190°C for about 30-35 minutes until bubbly and golden on top.

Top Tip

From my experience, getting the sauce just right makes all the difference—too thick and it’s clumpy; too thin and it won’t hold the roll-ups together nicely. Here are some of my must-know tricks:

Smooth Sauce Technique: Whisk continuously when adding milk and cream to avoid lumps—patience here pays off big time!
Don’t Overcook Pasta: Leave noodles slightly firmer than you’d usually like—they’ll finish cooking in the oven and you’ll avoid mushy roll-ups.
Roll Tightly: Rolling the noodles firmly but gently prevents fillings from spilling out and keeps each roll neat and tidy.
Even Sauce Layer: Spread sauce evenly on the bottom of the pan to avoid any sticking and to keep moisture consistent across all rolls.

How to Serve Creamy Chicken Alfredo Lasagna Roll-Ups Recipe

Chicken Alfredo Lasagna - Serving Suggestion

Garnishes

I always finish mine with a sprinkle of freshly chopped parsley—its fresh, peppery flavor cuts through the richness and adds a lovely pop of color. Sometimes I add a little cracked black pepper on top for a rustic touch that looks gorgeous on the plate.

Side Dishes

My go-to sides here are a simple green salad with lemon vinaigrette to lighten things up, or roasted garlic green beans for that perfect balance of crisp and tender. A crusty bread to soak up any leftover Alfredo sauce is also a must in my book!

Creative Ways to Present

I once brought this dish to a dinner party and arranged the roll-ups like little lasagna roses in a round baking dish—it made for such a charming presentation and impressed everyone. You can also serve each roll-up individually with a drizzle of extra sauce and a sprinkle of parsley for a restaurant-style touch at home.

Make Ahead and Storage

Storing Leftovers

I store leftovers in an airtight container in the fridge, and they keep well for up to 3 days. Reheating gently in the oven or microwave preserves the creamy texture and keeps the cheese beautifully melty.

Freezing

This recipe freezes wonderfully! I wrap individual roll-ups tightly in foil or plastic wrap, then place them in a freezer bag. When I want a quick meal, I just thaw overnight in the fridge and bake as usual—still creamy and delicious, no compromise.

Reheating

Reheat leftovers at 350°F (175°C) covered with foil for about 20 minutes, then uncover for the last 5 minutes to crisp up the top. If using a microwave, cover loosely and heat in short bursts to avoid drying out.

Frequently Asked Questions:

Can I use store-bought Alfredo sauce for this recipe?

Absolutely! Store-bought Alfredo sauce can save time and still taste great. Just be sure to add some freshly grated Parmesan to boost flavor if you go that route.

What can I substitute for chicken in this recipe?

You can use cooked turkey, diced ham, or even sautéed mushrooms for a vegetarian twist. Just make sure whatever you add is cooked and shredded or chopped into manageable pieces for rolling.

How do I prevent the lasagna noodles from breaking when rolling?

Cook the noodles al dente and handle them gently when they're warm but not hot. Keeping them submerged in room temperature water helps prevent sticking and tearing, making them easier to roll.

Can I prepare these roll-ups ahead of time?

Yes! You can assemble the roll-ups, cover tightly, and refrigerate for up to 24 hours before baking. This makes them perfect for planning meals ahead and busy weeknights.

Final Thoughts

Honestly, this Creamy Chicken Alfredo Lasagna Roll-Ups Recipe is one of those dishes I keep coming back to whenever I want something comforting but a little special. It’s not just dinner—it’s an experience, full of warm flavors and buttery goodness swirled into the perfect roll. I can’t wait for you to try it and make it your own!